Synthesis and bioevaluation of new tacrine-cinnamic acid hybrids as cholinesterase inhibitors against Alzheimer’s disease

Small molecule cholinesterases inhibitor (ChEI) provides an effective therapeutic strategy to treat Alzheimer’s disease (AD). Currently, the discovery of new ChEI with multi-target effect is still of great importance. Herein, we report the synthesis, structure–activity relationship study and biologi...

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Detalles Bibliográficos
Autores principales: Chen, Yao, Zhu, Jie, Mo, Jun, Yang, Hongyu, Jiang, Xueyang, Lin, Hongzhi, Gu, Kai, Pei, Yuqiong, Wu, Liang, Tan, Renxiang, Hou, Jing, Chen, Jingyi, Lv, Yang, Bian, Yaoyao, Sun, Haopeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011792/
https://www.ncbi.nlm.nih.gov/pubmed/29278947
http://dx.doi.org/10.1080/14756366.2017.1412314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011792/
https://www.ncbi.nlm.nih.gov/pubmed/29278947
http://dx.doi.org/10.1080/14756366.2017.1412314

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