Discovery of novel PDE9A inhibitors with antioxidant activities for treatment of Alzheimer’s disease

Phosphodiesterase-9 (PDE9) is a promising target for treatment of Alzheimer’s disease (AD). To discover multifunctional anti-AD agents with capability of PDE9 inhibition and antioxidant activity, a series of novel pyrazolopyrimidinone derivatives, coupling with the pharmacophore of antioxidants such...

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Detalles Bibliográficos
Autores principales: Zhang, Chen, Zhou, Qian, Wu, Xu-Nian, Huang, Ya-Dan, Zhou, Jie, Lai, Zengwei, Wu, Yinuo, Luo, Hai-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011943/
https://www.ncbi.nlm.nih.gov/pubmed/29271265
http://dx.doi.org/10.1080/14756366.2017.1412315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011943/
https://www.ncbi.nlm.nih.gov/pubmed/29271265
http://dx.doi.org/10.1080/14756366.2017.1412315

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