Association of functional variants and protein-to-protein physical interactions of human MutY homolog linked with familial adenomatous polyposis and colorectal cancer syndrome

The human gene MUTYH codes for a DNA glycosylase involved in the repair of oxidative DNA damage. Faulty MUTYH protein activity causes the accumulation of G→T transversions due to unrepaired 8-oxoG:A mismatches. MUTYH germ-line mutations in humans are linked with a recessive form of Familial Adenomat...

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Detalles Bibliográficos
Autores principales: Abduljaleel, Zainularifeen, Athar, Mohammad, Al-Allaf, Faisal A., Al-Dehlawi, Saied, Vazquez, Jose R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012779/
https://www.ncbi.nlm.nih.gov/pubmed/32072083
http://dx.doi.org/10.1016/j.ncrna.2019.11.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012779/
https://www.ncbi.nlm.nih.gov/pubmed/32072083
http://dx.doi.org/10.1016/j.ncrna.2019.11.005

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