Cargando…

Association of functional variants and protein-to-protein physical interactions of human MutY homolog linked with familial adenomatous polyposis and colorectal cancer syndrome

The human gene MUTYH codes for a DNA glycosylase involved in the repair of oxidative DNA damage. Faulty MUTYH protein activity causes the accumulation of G→T transversions due to unrepaired 8-oxoG:A mismatches. MUTYH germ-line mutations in humans are linked with a recessive form of Familial Adenomat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abduljaleel, Zainularifeen, Athar, Mohammad, Al-Allaf, Faisal A., Al-Dehlawi, Saied, Vazquez, Jose R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	KeAi Publishing 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012779/ https://www.ncbi.nlm.nih.gov/pubmed/32072083 http://dx.doi.org/10.1016/j.ncrna.2019.11.005

Ejemplares similares

Synonymous mutation adenomatous polyposis coli(Δ486s) affects exon splicing and may predispose patients to adenomatous polyposis coli/mutY DNA glycosylase mutation-negative familial adenomatous polyposis
por: Liu, Wei Qing, et al.
Publicado: (2018)

Adenine DNA Glycosylase Activity of 14 Human MutY Homolog (MUTYH) Variant Proteins Found in Patients with Colorectal Polyposis and Cancer
por: Goto, Masanori, et al.
Publicado: (2010)

MutY-Homolog (MYH) inhibition reduces pancreatic cancer cell growth and increases chemosensitivity
por: Sharbeen, George, et al.
Publicado: (2016)

Mammalian MutY Homolog (MYH or MUTYH) is Critical for Telomere Integrity under Oxidative Stress
por: Gupta, Aditi, et al.
Publicado: (2022)

The Presence of the DNA Repair Genes mutM, mutY, mutL, and mutS is Related to Proteome Size in Bacterial Genomes
por: Garcia-Gonzalez, Aurian, et al.
Publicado: (2012)

Peptides-based vaccine against SARS-nCoV-2 antigenic fragmented synthetic epitopes recognized by T cell and β-cell initiation of specific antibodies to fight the infection
por: Abduljaleel, Zainularifeen, et al.
Publicado: (2021)

Immunopurification of adenomatous polyposis coli (APC) proteins
por: Elliott, Kerryn L, et al.
Publicado: (2013)

Novel LDLR Variant in Familial Hypercholesterolemia: NGS-Based Identification, In Silico Characterization, and Pharmacogenetic Insights
por: Athar, Mohammad, et al.
Publicado: (2023)

Familial adenomatous polyposis
por: Half, Elizabeth, et al.
Publicado: (2009)

Adenomatous Polyposis Coli Gene Mutations in 22 Chinese Pedigrees with Familial Adenomatous Polyposis
por: Wang, Dan, et al.
Publicado: (2019)

Mutis /
por: Guiochíns, Elena, 1969-
Publicado: (2005)

Characterization of Adenomatous Polyposis Coli Protein Dynamics and Localization at the Centrosome
por: Lui, Christina, et al.
Publicado: (2016)

Mutation profiling of anaplastic ependymoma grade III by Ion Proton next generation DNA sequencing
por: Butt, Ejaz, et al.
Publicado: (2020)

Multiple Adenomatous Duodenal Polyposis
por: Zádorová, Zdena, et al.
Publicado: (2013)

Familial adenomatous polyposis of the colon
por: Plawski, Andrzej, et al.
Publicado: (2013)

Attenuated Familial Adenomatous Polyposis
por: Eizuka, Makoto, et al.
Publicado: (2023)

Functional Complementation Assay for 47 MUTYH Variants in a MutY-Disrupted Escherichia Coli Strain
por: Komine, Keigo, et al.
Publicado: (2015)

Familial Adenomatous Polyposis (FAP) and Other Polyposis Syndromes
por: Scott, Rodney J
Publicado: (2003)

Functional characterization of two human MutY homolog (hMYH) missense mutations (R227W and V232F) that lie within the putative hMSH6 binding domain and are associated with hMYH polyposis
por: Bai, Haibo, et al.
Publicado: (2005)

APC gene mutations and colorectal adenomatosis in familial adenomatous polyposis
por: Ficari, F, et al.
Publicado: (2000)

Alternative treatments for prophylaxis of colorectal cancer in familial adenomatous polyposis
por: Takeshita, Emiko, et al.
Publicado: (2018)

Evidence of Trem2 Variant Associated with Triple Risk of Alzheimer’s Disease
por: Abduljaleel, Zainularifeen, et al.
Publicado: (2014)

Molecular Analysis of Factor VIII and Factor IX Genes in Hemophilia Patients: Identification of Novel Mutations and Molecular Dynamics Studies
por: Al-Allaf, Faisal A., et al.
Publicado: (2017)

The Adenomatous Polyposis Coli Protein Contributes to Normal Compaction of Mitotic Chromatin
por: Dikovskaya, Dina, et al.
Publicado: (2012)

Insights into the role of Val45 and Gln182 of Escherichia coli MutY in DNA substrate binding and specificity
por: Chang, Po-Wen, et al.
Publicado: (2009)

Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases
por: Woods, Ryan D., et al.
Publicado: (2016)

Structure–Activity Relationships Reveal Key Features of 8-Oxoguanine: A Mismatch Detection by the MutY Glycosylase
por: Manlove, Amelia H., et al.
Publicado: (2017)

Therapeutic targeting truncated adenomatous polyposis coli (APC) proteins for the selective killing of colorectal cancer cells
por: Zhang, Lu, et al.
Publicado: (2014)

Familial adenomatous polyposis and desmoid tumors
por: Righetti, Ana Elisa Moraes, et al.
Publicado: (2011)

Surgical treatment in familial adenomatous polyposis
por: Tudyka, Vera N., et al.
Publicado: (2012)

Celestino Mutis
por: Martín Ferrero, Paz
Publicado: (1987)

Identification of a novel nonsense variant c.1332dup, p.(D445*) in the LDLR gene that causes familial hypercholesterolemia
por: Al-Allaf, Faisal A, et al.
Publicado: (2014)

Extracolonic features of familial adenomatous polyposis in patients with sporadic colorectal cancer.
por: Dunlop, M. G., et al.
Publicado: (1996)

Familial Adenomatous Polyposis with Synchronous Colorectal, Bilateral Ovarian, and Uterine Malignancies
por: Prasad, Bipin Thomas, et al.
Publicado: (2021)

Morphological Analyses of Colorectal Adenocarcinomas in Japanese Familial Adenomatous Polyposis Patients
por: Suzuki, Yozo, et al.
Publicado: (2022)

Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria
por: Ohtsubo, T., et al.
Publicado: (2015)

Comprehensive structure-function analysis of causative variants in retinal pigment epithelium specific 65 kDa protein associated Leber Congenital Amaurosis
por: Abduljaleel, Zainularifeen
Publicado: (2019)

Structural snapshots of base excision by the cancer-associated variant MutY N146S reveal a retaining mechanism
por: Demir, Merve, et al.
Publicado: (2023)

Molecular Basis for the Recognition of Adenomatous Polyposis Coli by the Discs Large 1 Protein
por: Zhang, Zhenyi, et al.
Publicado: (2011)

A novel large germ line deletion in adenomatous polyposis coli (APC) gene associated with familial adenomatous polyposis
por: Pouya, Farzaneh, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ign9lkavffoe9m9qpqfdtqia3s