A Fast and Sensitive Luciferase-based Assay for Antibody Engineering and Design of Chimeric Antigen Receptors

Success of immunotherapeutic approaches using genetically engineered antibodies and T cells modified with chimeric antigen receptors (CARs) depends, among other things, on the selection of antigen binding domains with desirable expression and binding characteristics. We developed a luciferase-based...

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Detalles Bibliográficos
Autores principales: Natarajan, Venkatesh, Gopalakrishnan, Ramakrishnan, Matta, Hittu, Choi, Sunju, Gong, Songjie, Jeronimo, Alberto, Keerthipati, Pooja Smruthi, Morales, Anthony, Venkatesh, Harishwar, Chaudhary, Preet M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012821/
https://www.ncbi.nlm.nih.gov/pubmed/32047180
http://dx.doi.org/10.1038/s41598-020-59099-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012821/
https://www.ncbi.nlm.nih.gov/pubmed/32047180
http://dx.doi.org/10.1038/s41598-020-59099-9

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