Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors

Following assembly, the anthrax protective antigen (PA) forms an oligomeric translocon that unfolds and translocates either its lethal factor (LF) or edema factor (EF) into the host cell. Here, we report the cryo-EM structures of heptameric PA channels with partially unfolded LF and EF at 4.6 and 3....

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Detalles Bibliográficos
Autores principales: Hardenbrook, Nathan J., Liu, Shiheng, Zhou, Kang, Ghosal, Koyel, Zhou, Z. Hong, Krantz, Bryan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012834/
https://www.ncbi.nlm.nih.gov/pubmed/32047164
http://dx.doi.org/10.1038/s41467-020-14658-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012834/
https://www.ncbi.nlm.nih.gov/pubmed/32047164
http://dx.doi.org/10.1038/s41467-020-14658-6

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