Discoidin Domain Receptors, DDR1b and DDR2, Promote Tumour Growth within Collagen but DDR1b Suppresses Experimental Lung Metastasis in HT1080 Xenografts

The Discoidin Domain Receptors (DDRs) constitute a unique set of receptor tyrosine kinases that signal in response to collagen. Using an inducible expression system in human HT1080 fibrosarcoma cells, we investigated the role of DDR1b and DDR2 on primary tumour growth and experimental lung metastase...

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Detalles Bibliográficos
Autores principales: Wasinski, Benjamin, Sohail, Anjum, Bonfil, R. Daniel, Kim, Seongho, Saliganan, Allen, Polin, Lisa, Bouhamdan, Mohamad, Kim, Hyeong-Reh C., Prunotto, Marco, Fridman, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012844/
https://www.ncbi.nlm.nih.gov/pubmed/32047176
http://dx.doi.org/10.1038/s41598-020-59028-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012844/
https://www.ncbi.nlm.nih.gov/pubmed/32047176
http://dx.doi.org/10.1038/s41598-020-59028-w

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