Cargando…

Synthesis, Bioevaluation, Structure-Activity Relationship and Docking Studies of Natural Product Inspired (Z)-3-benzylideneisobenzofuran-1(3H)-ones as Highly Potent antioxidants and Antiplatelet agents

For the first time, a series of highly potent natural product inspired substituted (Z)-3-benzylideneisobenzofuran-1(3H)-ones 28a-t, embraced with electron-withdrawing groups (EWG) and electron-donating groups (EDG) at site I and site II, were prepared and assessed for their in vitro antioxidant acti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shyamlal, Bharti Rajesh Kumar, Yadav, Lalit, Tiwari, Mohit K., Mathur, Manas, Prikhodko, Jaroslav I., Mashevskaya, Irina V., Yadav, Dharmendra K., Chaudhary, Sandeep
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012914/ https://www.ncbi.nlm.nih.gov/pubmed/32047204 http://dx.doi.org/10.1038/s41598-020-59218-6

Ejemplares similares

Ag(2)O nanoparticle-catalyzed substrate-controlled regioselectivities: direct access to 3-ylidenephthalides and isocoumarins
por: Chaudhary, Sandeep, et al.
Publicado: (2018)

Discovery of C-3 Tethered 2-oxo-benzo[1,4]oxazines as Potent Antioxidants: Bio-Inspired Based Design, Synthesis, Biological Evaluation, Cytotoxic, and in Silico Molecular Docking Studies
por: Sharma, Vashundhra, et al.
Publicado: (2018)

Dehydroisohispanolone as a Promising NLRP3 Inhibitor Agent: Bioevaluation and Molecular Docking
por: González-Cofrade, Laura, et al.
Publicado: (2022)

Natural-Product-Inspired Microwave-Assisted Synthesis of Novel Spirooxindoles as Antileishmanial Agents: Synthesis, Stereochemical Assignment, Bioevaluation, SAR, and Molecular Docking Studies
por: Sahu, Nawal Kishore, et al.
Publicado: (2023)

New 1,2,3-Triazole-Appended Bis-pyrazoles: Synthesis, Bioevaluation, and Molecular Docking
por: Danne, Ashruba B., et al.
Publicado: (2021)

Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors
por: Prior, Allan M., et al.
Publicado: (2013)

Promising Antibacterial and Antifungal Agents Based on Thiolated Vitamin K3 Analogs: Synthesis, Bioevaluation, Molecular Docking
por: Yıldırım, Hatice, et al.
Publicado: (2022)

Inverse docking based screening and identification of protein targets for Cassiarin alkaloids against Plasmodium falciparum
por: Negi, Arvind, et al.
Publicado: (2018)

Microwave-assisted synthesis and bioevaluation of new sulfonamides
por: Gul, Halise Inci, et al.
Publicado: (2017)

Dexibuprofen amide derivatives as potential anticancer agents: synthesis, in silico docking, bioevaluation, and molecular dynamic simulation
por: Ashraf, Zaman, et al.
Publicado: (2019)

Synthesis, Preliminary Bioevaluation and Computational Analysis of Caffeic Acid Analogues
por: Liu, Zhiqian, et al.
Publicado: (2014)

Design, Synthesis and in Combo Antidiabetic Bioevaluation of Multitarget Phenylpropanoic Acids †
por: Colín-Lozano, Blanca, et al.
Publicado: (2018)

Synthesis and bioevaluation of thienopyrimidines bearing a pyrazoline unit as selective PI3Kα inhibitors
por: Lai, Luogen, et al.
Publicado: (2019)

Design, Syntheses, and Bioevaluations of Some Novel N(2)-Acryloylbenzohydrazides as Chemostimulants and Cytotoxic Agents
por: Lakhani, Kinjal, et al.
Publicado: (2021)

Molecular Insights into the Interaction of RONS and Thieno[3,2-c]pyran Analogs with SIRT6/COX-2: A Molecular Dynamics Study
por: Yadav, Dharmendra K., et al.
Publicado: (2018)

Synthesis and bioevaluation of N,4-diaryl-1,3-thiazole-2-amines as tubulin inhibitors with potent antiproliferative activity
por: Sun, Maolin, et al.
Publicado: (2017)

Bioevaluation of (125)I Ocu-Prosta seeds for application in prostate cancer brachytherapy
por: Mukherjee, Archana, et al.
Publicado: (2014)

Synthesis, Bioevaluation and Molecular Dynamic Simulation Studies of Dexibuprofen–Antioxidant Mutual Prodrugs
por: Ashraf, Zaman, et al.
Publicado: (2016)

Synthesis and bioevaluation of novel steroidal isatin conjugates derived from epiandrosterone/androsterone
por: Ke, Shaoyong, et al.
Publicado: (2019)

Bioevaluation of superparamagnetic iron oxide nanoparticles (SPIONs) functionalized with dihexadecyl phosphate (DHP)
por: Mieloch, Adam Aron, et al.
Publicado: (2020)

Design, synthesis and bioevaluation of novel 6-substituted aminoindazole derivatives as anticancer agents
por: Hoang, Ngo Xuan, et al.
Publicado: (2020)

Oxidative cross-dehydrogenative coupling (CDC) via C((sp(2)))–H bond functionalization: tert-butyl peroxybenzoate (TBPB)-promoted regioselective direct C-3 acylation/benzoylation of 2H-indazoles with aldehydes/benzyl alcohols/styrenes
por: Sharma, Richa, et al.
Publicado: (2021)

Computational Modeling on Aquaporin-3 as Skin Cancer Target: A Virtual Screening Study
por: Yadav, Dharmendra Kumar, et al.
Publicado: (2020)

Bioevaluation of magnetic mesoporous silica rods: cytotoxicity, cell uptake and biodistribution in zebrafish and rodents
por: Grzelak, Jan, et al.
Publicado: (2022)

Evaluation of immunomodulatory activity of “Shirishavaleha”–An Ayurvedic compound formulation in albino rats
por: Yadav, Shyamlal Singh, et al.
Publicado: (2011)

Clinical efficacy of two different samples of Shirishavaleha in Tamaka Shwasa (Bronchial Asthma)
por: Yadav, Shyamlal Singh, et al.
Publicado: (2012)

Synthesis and bioevaluation of new tacrine-cinnamic acid hybrids as cholinesterase inhibitors against Alzheimer’s disease
por: Chen, Yao, et al.
Publicado: (2017)

Anti-inflammatory activity of Shirishavaleha: An Ayurvedic compound formulation
por: Yadav, Shyamlal Singh, et al.
Publicado: (2010)

Standardization of Shirishavaleha with reference to physico-chemical characteristics
por: Yadav, Shyamlal Singh, et al.
Publicado: (2011)

Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents
por: Derita, Marcos, et al.
Publicado: (2013)

Bioevaluation of Ranatuerin-2Pb from the Frog Skin Secretion of Rana pipiens and Its Truncated Analogues
por: Zhou, Xiaowei, et al.
Publicado: (2019)

Bioevaluation and Targeted Modification of Temporin-FL From the Skin Secretion of Dark-Spotted Frog (Pelophylax nigromaculatus)
por: Wang, Wenjie, et al.
Publicado: (2021)

Facial Synthesis and Bioevaluation of Well-Defined OEGylated Betulinic Acid-Cyclodextrin Conjugates for Inhibition of Influenza Infection
por: Chen, Yingying, et al.
Publicado: (2022)

New Succinimide–Thiazolidinedione Hybrids as Multitarget Antidiabetic Agents: Design, Synthesis, Bioevaluation, and Molecular Modelling Studies
por: Huneif, Mohammed A., et al.
Publicado: (2023)

Bioevaluation of Novel Anti-Biofilm Coatings Based on PVP/Fe(3)O(4) Nanostructures and 2-((4-Ethylphenoxy)methyl)-N-(arylcarbamothioyl)benzamides
por: Limban, Carmen, et al.
Publicado: (2014)

Oxidative Stress and Nano-Toxicity Induced by TiO(2) and ZnO on WAG Cell Line
por: Dubey, Akhilesh, et al.
Publicado: (2015)

Sarcandra glabra (Caoshanhu) protects mesenchymal stem cells from oxidative stress: a bioevaluation and mechanistic chemistry
por: Liu, Jingjing, et al.
Publicado: (2016)

Synthesis and Bioevaluation of Iodine-131 Directly Labeled Cyclic RGD-PEGylated Gold Nanorods for Tumor-Targeted Imaging
por: Zhang, Yingying, et al.
Publicado: (2017)

Rapid on-site evaluation with BIOEVALUATOR(®) during endobronchial ultrasound-guided transbronchial needle aspiration for diagnosing pulmonary and mediastinal diseases
por: Minami, Daisuke, et al.
Publicado: (2014)

A Standard Protocol for the Production and Bioevaluation of Ethical In Vivo Models of HPV-Negative Head and Neck Squamous Cell Carcinoma
por: Sarogni, Patrizia, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1kplplb3nnodb1jg7uipvo76ks