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Biguanides in combination with olaparib limits tumorigenesis of drug‐resistant ovarian cancer cells through inhibition of Snail

Ovarian cancer is the most lethal gynecological malignancy. Currently, new chemotherapeutic strategies are required to improve patient outcome and survival. Biguanides, classic anti‐diabetic drugs, have gained importance for theiri antitumor potency demonstrated by various studies. Olaparib is a PAR...

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Detalles Bibliográficos
Autores principales: Wang, Qiong, López‐Ozuna, Vanessa M., Baloch, Tahira, Bithras, Joanne, Amin, Oreekha, Kessous, Roy, Kogan, Liron, Laskov, Ido, Yasmeen, Amber
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013055/
https://www.ncbi.nlm.nih.gov/pubmed/31863638
http://dx.doi.org/10.1002/cam4.2738