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An insulin-inducible transcription factor, SHARP-1, represses transcription of the SIRT1 longevity gene

The rat enhancer of split- and hairy-related protein (SHARP)-1 genes encode insulin-inducible transcriptional repressors. A longevity gene, sirtuin 1 (SIRT1) encodes protein deacetylase. These play an important role in regulating hepatic glucose metabolism. In this study, to evaluate a correlation w...

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Detalles Bibliográficos
Autores principales: Asano, Kosuke, Tsukada, Akiko, Takagi, Katsuhiro, Yamada, Kazuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013158/
https://www.ncbi.nlm.nih.gov/pubmed/32072026
http://dx.doi.org/10.1016/j.bbrep.2020.100743