Cargando…
A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target
BACKGROUND AND AIMS: GAS6 signaling, through the TAM receptor tyrosine kinases AXL and MERTK, participates in chronic liver pathologies. Here, we addressed GAS6/TAM involvement in Non-Alcoholic SteatoHepatitis (NASH) development. METHODS: GAS6/TAM signaling was analyzed in cultured primary hepatocyt...
Autores principales: | Tutusaus, Anna, de Gregorio, Estefanía, Cucarull, Blanca, Cristóbal, Helena, Aresté, Cristina, Graupera, Isabel, Coll, Mar, Colell, Anna, Gausdal, Gro, Lorens, James B., García de Frutos, Pablo, Morales, Albert, Marí, Montserrat |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013198/ https://www.ncbi.nlm.nih.gov/pubmed/31689560 http://dx.doi.org/10.1016/j.jcmgh.2019.10.010 |
Ejemplares similares
-
Mitochondrial Glutathione: Recent Insights and Role in Disease
por: Marí, Montserrat, et al.
Publicado: (2020) -
Antioxidants Threaten Multikinase Inhibitor Efficacy against Liver Cancer by Blocking Mitochondrial Reactive Oxygen Species
por: Cucarull, Blanca, et al.
Publicado: (2021) -
Hepatocellular Carcinoma: Molecular Pathogenesis and Therapeutic Advances
por: Cucarull, Blanca, et al.
Publicado: (2022) -
Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice
por: Cuño-Gómiz, Carlos, et al.
Publicado: (2023) -
Regorafenib Alteration of the BCL-xL/MCL-1 Ratio Provides a Therapeutic Opportunity for BH3-Mimetics in Hepatocellular Carcinoma Models
por: Cucarull, Blanca, et al.
Publicado: (2020)