Enhancing Hematopoiesis from Murine Embryonic Stem Cells through MLL1-Induced Activation of a Rac/Rho/Integrin Signaling Axis

The Mixed Lineage Leukemia (MLL1, KMT2A) gene is critical for development and maintenance of hematopoietic stem cells (HSCs), however, whether this protein is limiting for HSC development is unknown due to lack of physiologic model systems. Here, we develop an MLL1-inducible embryonic stem cell (ESC...

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Detalles Bibliográficos
Autores principales: Yang, Weiwei, Trahan, G. Devon, Howell, Elizabeth D., Speck, Nancy A., Jones, Kenneth L., Gillen, Austin E., Riemondy, Kent, Hesselberth, Jay, Bryder, David, Ernst, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013201/
https://www.ncbi.nlm.nih.gov/pubmed/31951812
http://dx.doi.org/10.1016/j.stemcr.2019.12.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013201/
https://www.ncbi.nlm.nih.gov/pubmed/31951812
http://dx.doi.org/10.1016/j.stemcr.2019.12.009

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