Critical Role for P53 in Regulating the Cell Cycle of Ground State Embryonic Stem Cells

Mouse embryonic stem cells (ESCs) grown in serum-supplemented conditions are characterized by an extremely short G1 phase due to the lack of G1-phase control. Concordantly, the G1-phase-specific P53-P21 pathway is compromised in serum ESCs. Here, we provide evidence that P53 is activated upon transi...

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Detalles Bibliográficos
Autores principales: ter Huurne, Menno, Peng, Tianran, Yi, Guoqiang, van Mierlo, Guido, Marks, Hendrik, Stunnenberg, Hendrik G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013234/
https://www.ncbi.nlm.nih.gov/pubmed/32004494
http://dx.doi.org/10.1016/j.stemcr.2020.01.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013234/
https://www.ncbi.nlm.nih.gov/pubmed/32004494
http://dx.doi.org/10.1016/j.stemcr.2020.01.001

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