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Critical Role for P53 in Regulating the Cell Cycle of Ground State Embryonic Stem Cells

Mouse embryonic stem cells (ESCs) grown in serum-supplemented conditions are characterized by an extremely short G1 phase due to the lack of G1-phase control. Concordantly, the G1-phase-specific P53-P21 pathway is compromised in serum ESCs. Here, we provide evidence that P53 is activated upon transi...

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Detalles Bibliográficos
Autores principales:	ter Huurne, Menno, Peng, Tianran, Yi, Guoqiang, van Mierlo, Guido, Marks, Hendrik, Stunnenberg, Hendrik G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013234/ https://www.ncbi.nlm.nih.gov/pubmed/32004494 http://dx.doi.org/10.1016/j.stemcr.2020.01.001

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