Partial Inhibition of RNA Polymerase I Promotes Animal Health and Longevity

Health and survival in old age can be improved by changes in gene expression. RNA polymerase (Pol) I is the essential, conserved enzyme whose task is to generate the pre-ribosomal RNA (rRNA). We find that reducing the levels of Pol I activity is sufficient to extend lifespan in the fruit fly. This e...

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Detalles Bibliográficos
Autores principales: Martínez Corrales, Guillermo, Filer, Danny, Wenz, Katharina C., Rogan, Abbie, Phillips, George, Li, Mengjia, Feseha, Yodit, Broughton, Susan J., Alic, Nazif
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013379/
https://www.ncbi.nlm.nih.gov/pubmed/32049000
http://dx.doi.org/10.1016/j.celrep.2020.01.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013379/
https://www.ncbi.nlm.nih.gov/pubmed/32049000
http://dx.doi.org/10.1016/j.celrep.2020.01.017

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