Unveiling the Molecular Basis of the Noonan Syndrome-Causing Mutation T42A of SHP2

Noonan syndrome (NS) is a genetic disorder caused by the hyperactivation of the RAS-MAPK molecular pathway. About 50% of NS cases are caused by mutations affecting the SHP2 protein, a multi-domain phosphatase with a fundamental role in the regulation of the RAS-MAPK pathway. Most NS-causing mutation...

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Detalles Bibliográficos
Autores principales: Toto, Angelo, Malagrinò, Francesca, Visconti, Lorenzo, Troilo, Francesca, Gianni, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013464/
https://www.ncbi.nlm.nih.gov/pubmed/31936901
http://dx.doi.org/10.3390/ijms21020461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013464/
https://www.ncbi.nlm.nih.gov/pubmed/31936901
http://dx.doi.org/10.3390/ijms21020461

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