Synthesis, CYP24A1-Dependent Metabolism and Antiproliferative Potential against Colorectal Cancer Cells of 1,25-Dihydroxyvitamin D(2) Derivatives Modified at the Side Chain and the A-Ring

Experimental data indicate that low-calcemic vitamin D derivatives (VDDs) exhibit anticancer properties, both in vitro and in vivo. In our search for a vitamin D analog as potential anticancer agent, we investigated the influence of chirality in the side chain of the derivatives of 1,25-dihydroxyerg...

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Detalles Bibliográficos
Autores principales: Milczarek, Magdalena, Chodyński, Michał, Pietraszek, Anita, Stachowicz-Suhs, Martyna, Yasuda, Kaori, Sakaki, Toshiyuki, Wietrzyk, Joanna, Kutner, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013581/
https://www.ncbi.nlm.nih.gov/pubmed/31963716
http://dx.doi.org/10.3390/ijms21020642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013581/
https://www.ncbi.nlm.nih.gov/pubmed/31963716
http://dx.doi.org/10.3390/ijms21020642

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