Synthesis of Spin-Labelled Bergamottin: A Potent CYP3A4 Inhibitor with Antiproliferative Activity

Bergamottin (BM, 1), a component of grapefruit juice, acts as an inhibitor of some isoforms of the cytochrome P450 (CYP) enzyme, particularly CYP3A4. Herein, a new bergamottin containing a nitroxide moiety (SL-bergamottin, SL-BM, 10) was synthesized; chemically characterized, evaluated as a potentia...

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Detalles Bibliográficos
Autores principales: Zsidó, Balázs Zoltán, Balog, Mária, Erős, Nikolett, Poór, Miklós, Mohos, Violetta, Fliszár-Nyúl, Eszter, Hetényi, Csaba, Nagane, Masaki, Hideg, Kálmán, Kálai, Tamás, Bognár, Balázs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013880/
https://www.ncbi.nlm.nih.gov/pubmed/31941150
http://dx.doi.org/10.3390/ijms21020508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013880/
https://www.ncbi.nlm.nih.gov/pubmed/31941150
http://dx.doi.org/10.3390/ijms21020508

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