Components from the Human c-myb Transcriptional Regulation System Reactivate Epigenetically Repressed Transgenes

A persistent challenge for mammalian cell engineering is the undesirable epigenetic silencing of transgenes. Foreign DNA can be incorporated into closed chromatin before and after it has been integrated into a host cell’s genome. To identify elements that mitigate epigenetic silencing, we tested com...

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Detalles Bibliográficos
Autores principales: Barrett, Cassandra M., McCracken, Reilly, Elmer, Jacob, Haynes, Karmella A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014047/
https://www.ncbi.nlm.nih.gov/pubmed/31947658
http://dx.doi.org/10.3390/ijms21020530

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014047/
https://www.ncbi.nlm.nih.gov/pubmed/31947658
http://dx.doi.org/10.3390/ijms21020530

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