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Components from the Human c-myb Transcriptional Regulation System Reactivate Epigenetically Repressed Transgenes

A persistent challenge for mammalian cell engineering is the undesirable epigenetic silencing of transgenes. Foreign DNA can be incorporated into closed chromatin before and after it has been integrated into a host cell’s genome. To identify elements that mitigate epigenetic silencing, we tested com...

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Detalles Bibliográficos
Autores principales:	Barrett, Cassandra M., McCracken, Reilly, Elmer, Jacob, Haynes, Karmella A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014047/ https://www.ncbi.nlm.nih.gov/pubmed/31947658 http://dx.doi.org/10.3390/ijms21020530

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