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Combined Targeting of Mutant p53 and Jumonji Family Histone Demethylase Augments Therapeutic Efficacy of Radiation in H3K27M DIPG
Diffuse intrinsic pontine glioma (DIPG) is an aggressive pediatric brainstem tumor with a 5-year survival of <1%. Up to 80% of the DIPG tumors contain a specific K27M mutation in one of the two genes encoding histone H3 (H3K27M). Furthermore, p53 mutations found in >70–80% of H3K27M DIPG, and...
| Hauptverfasser: | , , |
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| Format: | Online Artikel Text |
| Sprache: | English |
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MDPI
2020
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| Online Zugang: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014308/ https://www.ncbi.nlm.nih.gov/pubmed/31940975 http://dx.doi.org/10.3390/ijms21020490 |