Age-Associated TET2 Mutations: Common Drivers of Myeloid Dysfunction, Cancer and Cardiovascular Disease

Acquired, inactivating mutations in Tet methylcytosine dioxygenase 2 (TET2) are detected in peripheral blood cells of a remarkable 5%–10% of adults greater than 65 years of age. They impart a hematopoietic stem cell advantage and resultant clonal hematopoiesis of indeterminate potential (CHIP) with...

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Detalles Bibliográficos
Autores principales: Ferrone, Christina K., Blydt-Hansen, Mackenzie, Rauh, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014315/
https://www.ncbi.nlm.nih.gov/pubmed/31963585
http://dx.doi.org/10.3390/ijms21020626

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014315/
https://www.ncbi.nlm.nih.gov/pubmed/31963585
http://dx.doi.org/10.3390/ijms21020626

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