Potent and Broad but not Unselective Cleavage of Cytokines and Chemokines by Human Neutrophil Elastase and Proteinase 3

In two recent studies we have shown that three of the most abundant human hematopoietic serine proteases—mast cell chymase, mast cell tryptase and neutrophil cathepsin G—show a highly selective cleavage of cytokines and chemokines with a strong preference for a few alarmins, including IL-18, TSLP an...

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Detalles Bibliográficos
Autores principales: Fu, Zhirong, Akula, Srinivas, Thorpe, Michael, Hellman, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014372/
https://www.ncbi.nlm.nih.gov/pubmed/31963828
http://dx.doi.org/10.3390/ijms21020651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014372/
https://www.ncbi.nlm.nih.gov/pubmed/31963828
http://dx.doi.org/10.3390/ijms21020651

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