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Potent and Broad but not Unselective Cleavage of Cytokines and Chemokines by Human Neutrophil Elastase and Proteinase 3

In two recent studies we have shown that three of the most abundant human hematopoietic serine proteases—mast cell chymase, mast cell tryptase and neutrophil cathepsin G—show a highly selective cleavage of cytokines and chemokines with a strong preference for a few alarmins, including IL-18, TSLP an...

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Detalles Bibliográficos
Autores principales:	Fu, Zhirong, Akula, Srinivas, Thorpe, Michael, Hellman, Lars
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014372/ https://www.ncbi.nlm.nih.gov/pubmed/31963828 http://dx.doi.org/10.3390/ijms21020651

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