A T cell–myeloid IL-10 axis regulates pathogenic IFN-γ–dependent immunity in a mouse model of type 2–low asthma

BACKGROUND: Although originally defined as a type 2 (T2) immune-mediated condition, non-T2 cytokines, such as IFN-γ and IL-17A, have been implicated in asthma pathogenesis, particularly in patients with severe disease. IL-10 regulates T(H) cell phenotypes and can dampen T2 immunity to allergens, but...

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Detalles Bibliográficos
Autores principales: Branchett, William J., Stölting, Helen, Oliver, Robert A., Walker, Simone A., Puttur, Franz, Gregory, Lisa G., Gabryšová, Leona, Wilson, Mark S., O'Garra, Anne, Lloyd, Clare M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mosby 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014588/
https://www.ncbi.nlm.nih.gov/pubmed/31445933
http://dx.doi.org/10.1016/j.jaci.2019.08.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014588/
https://www.ncbi.nlm.nih.gov/pubmed/31445933
http://dx.doi.org/10.1016/j.jaci.2019.08.006

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