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Mathematical deconvolution of CAR T-cell proliferation and exhaustion from real-time killing assay data
Chimeric antigen receptor (CAR) T-cell therapy has shown promise in the treatment of haematological cancers and is currently being investigated for solid tumours, including high-grade glioma brain tumours. There is a desperate need to quantitatively study the factors that contribute to the efficacy...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014796/ https://www.ncbi.nlm.nih.gov/pubmed/31937234 http://dx.doi.org/10.1098/rsif.2019.0734 |