(99m)Tc-MIBI uptake as a marker of mitochondrial membrane potential in cancer cells and effects of MDR1 and verapamil

We investigated the relation of (99m)Tc-MIBI uptake to mitochondrial membrane potential (MMP) in cancer cell lines and patient-derived tumor cells (PDCs). In T47D and HT29 cells with low MDR1 expression, FCCP dose-dependently reduced MMP and (99m)Tc-MIBI accumulation in similar patterns with nearly...

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Detalles Bibliográficos
Autores principales: Park, Jin Won, Hong, Sun-pyo, Lee, Jin Hee, Moon, Seung Hwan, Cho, Young Seok, Jung, Kyung-Ho, Lee, Jeeyun, Lee, Kyung-Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015412/
https://www.ncbi.nlm.nih.gov/pubmed/32050000
http://dx.doi.org/10.1371/journal.pone.0228848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015412/
https://www.ncbi.nlm.nih.gov/pubmed/32050000
http://dx.doi.org/10.1371/journal.pone.0228848

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