Cutting antiparallel DNA strands in a single active site

A single enzyme active site that catalyzes multiple reactions is a well-established biochemical theme, but how one nuclease site cleaves both DNA strands of a double helix has not been well understood. In analyzing site-specific DNA cleavage by the mammalian RAG1-RAG2 recombinase, which initiates V(...

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Detalles Bibliográficos
Autores principales: Chen, Xuemin, Cui, Yanxiang, Best, Robert B., Wang, Huaibin, Zhou, Z. Hong, Yang, Wei, Gellert, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015813/
https://www.ncbi.nlm.nih.gov/pubmed/32015552
http://dx.doi.org/10.1038/s41594-019-0363-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015813/
https://www.ncbi.nlm.nih.gov/pubmed/32015552
http://dx.doi.org/10.1038/s41594-019-0363-2

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