Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma

Although immune checkpoint inhibitors (ICIs) have achieved unprecedented results in melanoma, the biological features of the durable responses initiated by these drugs remain unknown. Here we show the genetic and phenotypic changes induced by treatment with programmed cell death-1 (PD-1) blockade in...

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Detalles Bibliográficos
Autores principales: Galvani, Elena, Mundra, Piyushkumar A., Valpione, Sara, Garcia-Martinez, Pablo, Smith, Matthew, Greenall, Jonathan, Thakur, Rohit, Helmink, Beth, Andrews, Miles C., Boon, Louis, Chester, Christopher, Gremel, Gabriela, Hogan, Kate, Mandal, Amit, Zeng, Kang, Banyard, Antonia, Ashton, Garry, Cook, Martin, Lorigan, Paul, Wargo, Jennifer A., Dhomen, Nathalie, Marais, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015935/
https://www.ncbi.nlm.nih.gov/pubmed/32051401
http://dx.doi.org/10.1038/s41467-020-14632-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015935/
https://www.ncbi.nlm.nih.gov/pubmed/32051401
http://dx.doi.org/10.1038/s41467-020-14632-2

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