The Heparan Sulfate Mimetic PG545 Modulates T Cell Responses and Prevents Delayed-Type Hypersensitivity

The heparan sulfate mimetic PG545 (pixatimod) is under evaluation as an inhibitor of angiogenesis and metastasis including in human clinical trials. We have examined the effects of PG545 on lymphocyte phenotypes and function. We report that PG545 treatment suppresses effector T cell activation and p...

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Detalles Bibliográficos
Autores principales: Koliesnik, Ievgen O., Kuipers, Hedwich F., Medina, Carlos O., Zihsler, Svenja, Liu, Dan, Van Belleghem, Jonas D., Bollyky, Paul L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015948/
https://www.ncbi.nlm.nih.gov/pubmed/32117279
http://dx.doi.org/10.3389/fimmu.2020.00132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015948/
https://www.ncbi.nlm.nih.gov/pubmed/32117279
http://dx.doi.org/10.3389/fimmu.2020.00132

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