β7 Integrin Inhibition Can Increase Intestinal Inflammation by Impairing Homing of CD25(hi)FoxP3(+) Regulatory T Cells

BACKGROUND & AIMS: Integrin α4β7 mediates lymphocyte trafficking to the gut and gut-associated lymphoid tissues, a process critical for recruitment of effector lymphocytes from the circulation to the gut mucosa in inflammatory bowel disease (IBD) and murine models of intestinal inflammation. Ant...

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Detalles Bibliográficos
Autores principales: Sun, Hao, Kuk, Wun, Rivera-Nieves, Jesús, Lopez-Ramirez, Miguel Alejandro, Eckmann, Lars, Ginsberg, Mark H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016000/
https://www.ncbi.nlm.nih.gov/pubmed/31707128
http://dx.doi.org/10.1016/j.jcmgh.2019.10.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016000/
https://www.ncbi.nlm.nih.gov/pubmed/31707128
http://dx.doi.org/10.1016/j.jcmgh.2019.10.012

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