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β7 Integrin Inhibition Can Increase Intestinal Inflammation by Impairing Homing of CD25(hi)FoxP3(+) Regulatory T Cells

BACKGROUND & AIMS: Integrin α4β7 mediates lymphocyte trafficking to the gut and gut-associated lymphoid tissues, a process critical for recruitment of effector lymphocytes from the circulation to the gut mucosa in inflammatory bowel disease (IBD) and murine models of intestinal inflammation. Ant...

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Detalles Bibliográficos
Autores principales:	Sun, Hao, Kuk, Wun, Rivera-Nieves, Jesús, Lopez-Ramirez, Miguel Alejandro, Eckmann, Lars, Ginsberg, Mark H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016000/ https://www.ncbi.nlm.nih.gov/pubmed/31707128 http://dx.doi.org/10.1016/j.jcmgh.2019.10.012

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