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Binding and Structural Properties of DNA Aptamers with VEGF-A-Mimic Activity

Vascular endothelial growth factors (VEGFs) are hypoxia-inducible secreted proteins to promote angiogenesis, in which VEGF-A is an important molecule that binds and activates VEGF receptor-1 (VEGFR-1) and VEGFR-2. In this study, two DNA aptamers, Apt01 and Apt02, were successfully isolated by altern...

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Detalles Bibliográficos
Autores principales:	Yoshitomi, Toru, Hayashi, Misako, Oguro, Takumi, Kimura, Keiko, Wayama, Fumiya, Furusho, Hitoshi, Yoshimoto, Keitaro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016029/ https://www.ncbi.nlm.nih.gov/pubmed/32059340 http://dx.doi.org/10.1016/j.omtn.2019.12.034

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