In vitro modeling of dendritic atrophy in Rett syndrome: determinants for phenotypic drug screening in neurodevelopmental disorders

Dendritic atrophy, defined as the reduction in complexity of the neuronal arborization, is a hallmark of several neurodevelopmental disorders, including Rett Syndrome (RTT). RTT, affecting 1:10,000 girls worldwide, is mainly caused by mutations in the MECP2 gene and has no cure. We describe here an...

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Detalles Bibliográficos
Autores principales: Nerli, Elisa, Roggero, Ottavia Maria, Baj, Gabriele, Tongiorgi, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016139/
https://www.ncbi.nlm.nih.gov/pubmed/32051524
http://dx.doi.org/10.1038/s41598-020-59268-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016139/
https://www.ncbi.nlm.nih.gov/pubmed/32051524
http://dx.doi.org/10.1038/s41598-020-59268-w

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