Nobiletin and its derivatives overcome multidrug resistance (MDR) in cancer: total synthesis and discovery of potent MDR reversal agents

Our recent studies demonstrated that the natural product nobiletin (NOB) served as a promising multidrug resistance (MDR) reversal agent and improved the effectiveness of cancer chemotherapy in vitro. However, low aqueous solubility and difficulty in total synthesis limited its application as a ther...

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Detalles Bibliográficos
Autores principales: Feng, Senling, Zhou, Huifang, Wu, Deyan, Zheng, Dechong, Qu, Biao, Liu, Ruiming, Zhang, Chen, Li, Zhe, Xie, Ying, Luo, Hai-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016283/
https://www.ncbi.nlm.nih.gov/pubmed/32082977
http://dx.doi.org/10.1016/j.apsb.2019.07.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016283/
https://www.ncbi.nlm.nih.gov/pubmed/32082977
http://dx.doi.org/10.1016/j.apsb.2019.07.007

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