CAR T Cell Generation by piggyBac Transposition from Linear Doggybone DNA Vectors Requires Transposon DNA-Flanking Regions

CD19-specific chimeric antigen receptor (CAR19) T cells, generated using viral vectors, are an efficacious but costly treatment for B cell malignancies. The nonviral piggyBac transposon system provides a simple and inexpensive alternative for CAR19 T cell production. Until now, piggyBac has been pla...

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Detalles Bibliográficos
Autores principales: Bishop, David C., Caproni, Lisa, Gowrishankar, Kavitha, Legiewicz, Michal, Karbowniczek, Kinga, Tite, John, Gottlieb, David J., Micklethwaite, Kenneth P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016334/
https://www.ncbi.nlm.nih.gov/pubmed/32071928
http://dx.doi.org/10.1016/j.omtm.2019.12.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016334/
https://www.ncbi.nlm.nih.gov/pubmed/32071928
http://dx.doi.org/10.1016/j.omtm.2019.12.020

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