Resistance to MET/VEGFR2 Inhibition by Cabozantinib Is Mediated by YAP/TBX5-Dependent Induction of FGFR1 in Castration-Resistant Prostate Cancer

The overall goal of this study was to elucidate the role of FGFR1 induction in acquired resistance to MET and VEGFR2 inhibition by cabozantinib in prostate cancer (PCa) and leverage this understanding to improve therapy outcomes. The response to cabozantinib was examined in mice bearing patient-deri...

Descripción completa

Detalles Bibliográficos
Autores principales: Koinis, Filippos, Corn, Paul, Parikh, Nila, Song, Jian, Vardaki, Ioulia, Mourkioti, Ioanna, Lin, Sue-Hwa, Logothetis, Christopher, Panaretakis, Theocharis, Gallick, Gary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016532/
https://www.ncbi.nlm.nih.gov/pubmed/31963871
http://dx.doi.org/10.3390/cancers12010244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016532/
https://www.ncbi.nlm.nih.gov/pubmed/31963871
http://dx.doi.org/10.3390/cancers12010244

Ejemplares similares