Polyhexamethylene Guanidine Phosphate Damages Tight Junctions and the F-Actin Architecture by Activating Calpain-1 via the P2RX7/Ca(2+) Signaling Pathway

Polyhexamethylene guanidine phosphate (PHMG-p), a member of the polymeric guanidine family, has strong antimicrobial activity and may increase the risk of inflammation-associated pulmonary fibrosis. However, the effect of PHMG-p on the barrier function of the bronchial epithelium is unknown. Epithel...

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Detalles Bibliográficos
Autores principales: Jin, Sun Woo, Lee, Gi Ho, Pham, Hoa Thi, Choi, Jae Ho, Jeong, Hye Gwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016582/
https://www.ncbi.nlm.nih.gov/pubmed/31878359
http://dx.doi.org/10.3390/cells9010059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016582/
https://www.ncbi.nlm.nih.gov/pubmed/31878359
http://dx.doi.org/10.3390/cells9010059

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