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The Mitotic Apparatus and Kinetochores in Microcephaly and Neurodevelopmental Diseases
Regulators of mitotic division, when dysfunctional or expressed in a deregulated manner (over- or underexpressed) in somatic cells, cause chromosome instability, which is a predisposing condition to cancer that is associated with unrestricted proliferation. Genes encoding mitotic regulators are grow...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016623/ https://www.ncbi.nlm.nih.gov/pubmed/31878213 http://dx.doi.org/10.3390/cells9010049 |
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author | Degrassi, Francesca Damizia, Michela Lavia, Patrizia |
author_facet | Degrassi, Francesca Damizia, Michela Lavia, Patrizia |
author_sort | Degrassi, Francesca |
collection | PubMed |
description | Regulators of mitotic division, when dysfunctional or expressed in a deregulated manner (over- or underexpressed) in somatic cells, cause chromosome instability, which is a predisposing condition to cancer that is associated with unrestricted proliferation. Genes encoding mitotic regulators are growingly implicated in neurodevelopmental diseases. Here, we briefly summarize existing knowledge on how microcephaly-related mitotic genes operate in the control of chromosome segregation during mitosis in somatic cells, with a special focus on the role of kinetochore factors. Then, we review evidence implicating mitotic apparatus- and kinetochore-resident factors in the origin of congenital microcephaly. We discuss data emerging from these works, which suggest a critical role of correct mitotic division in controlling neuronal cell proliferation and shaping the architecture of the central nervous system. |
format | Online Article Text |
id | pubmed-7016623 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70166232020-03-04 The Mitotic Apparatus and Kinetochores in Microcephaly and Neurodevelopmental Diseases Degrassi, Francesca Damizia, Michela Lavia, Patrizia Cells Review Regulators of mitotic division, when dysfunctional or expressed in a deregulated manner (over- or underexpressed) in somatic cells, cause chromosome instability, which is a predisposing condition to cancer that is associated with unrestricted proliferation. Genes encoding mitotic regulators are growingly implicated in neurodevelopmental diseases. Here, we briefly summarize existing knowledge on how microcephaly-related mitotic genes operate in the control of chromosome segregation during mitosis in somatic cells, with a special focus on the role of kinetochore factors. Then, we review evidence implicating mitotic apparatus- and kinetochore-resident factors in the origin of congenital microcephaly. We discuss data emerging from these works, which suggest a critical role of correct mitotic division in controlling neuronal cell proliferation and shaping the architecture of the central nervous system. MDPI 2019-12-24 /pmc/articles/PMC7016623/ /pubmed/31878213 http://dx.doi.org/10.3390/cells9010049 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Degrassi, Francesca Damizia, Michela Lavia, Patrizia The Mitotic Apparatus and Kinetochores in Microcephaly and Neurodevelopmental Diseases |
title | The Mitotic Apparatus and Kinetochores in Microcephaly and Neurodevelopmental Diseases |
title_full | The Mitotic Apparatus and Kinetochores in Microcephaly and Neurodevelopmental Diseases |
title_fullStr | The Mitotic Apparatus and Kinetochores in Microcephaly and Neurodevelopmental Diseases |
title_full_unstemmed | The Mitotic Apparatus and Kinetochores in Microcephaly and Neurodevelopmental Diseases |
title_short | The Mitotic Apparatus and Kinetochores in Microcephaly and Neurodevelopmental Diseases |
title_sort | mitotic apparatus and kinetochores in microcephaly and neurodevelopmental diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016623/ https://www.ncbi.nlm.nih.gov/pubmed/31878213 http://dx.doi.org/10.3390/cells9010049 |
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