Mutations That Confer Drug-Resistance, Oncogenicity and Intrinsic Activity on the ERK MAP Kinases—Current State of the Art

Unique characteristics distinguish extracellular signal-regulated kinases (Erks) from other eukaryotic protein kinases (ePKs). Unlike most ePKs, Erks do not autoactivate and they manifest no basal activity; they become catalysts only when dually phosphorylated on neighboring Thr and Tyr residues and...

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Detalles Bibliográficos
Autores principales: Smorodinsky-Atias, Karina, Soudah, Nadine, Engelberg, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016714/
https://www.ncbi.nlm.nih.gov/pubmed/31935908
http://dx.doi.org/10.3390/cells9010129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016714/
https://www.ncbi.nlm.nih.gov/pubmed/31935908
http://dx.doi.org/10.3390/cells9010129

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