Cargando…

Mutations That Confer Drug-Resistance, Oncogenicity and Intrinsic Activity on the ERK MAP Kinases—Current State of the Art

Unique characteristics distinguish extracellular signal-regulated kinases (Erks) from other eukaryotic protein kinases (ePKs). Unlike most ePKs, Erks do not autoactivate and they manifest no basal activity; they become catalysts only when dually phosphorylated on neighboring Thr and Tyr residues and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Smorodinsky-Atias, Karina, Soudah, Nadine, Engelberg, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016714/ https://www.ncbi.nlm.nih.gov/pubmed/31935908 http://dx.doi.org/10.3390/cells9010129

Ejemplares similares

A conserved arginine within the αC-helix of Erk1/2 is a latch of autoactivation and of oncogenic capabilities
por: Soudah, Nadine, et al.
Publicado: (2023)

Intrinsically active variants of Erk oncogenically transform cells and disclose unexpected autophosphorylation capability that is independent of TEY phosphorylation
por: Smorodinsky-Atias, Karina, et al.
Publicado: (2016)

Intrinsic Structural Disorder Confers Cellular Viability on Oncogenic Fusion Proteins
por: Hegyi, Hedi, et al.
Publicado: (2009)

Oncogenic mutation or overexpression of oncogenic KRAS or BRAF is not sufficient to confer oncogene addiction
por: Ito, Reina E., et al.
Publicado: (2021)

Mutation in the Common Docking Domain Affects MAP Kinase ERK2 Catalysis and Stability
por: Novak, Leonore, et al.
Publicado: (2023)

ERK MAP Kinase Signaling Regulates RAR Signaling to Confer Retinoid Resistance on Breast Cancer Cells
por: Hirota, Akira, et al.
Publicado: (2022)

ERK1 and ERK2 Map Kinases: Specific Roles or Functional Redundancy?
por: Buscà, Roser, et al.
Publicado: (2016)

Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2
por: Perander, Maria, et al.
Publicado: (2017)

Nuclear Export of Map Kinase (ERK) Involves a Map Kinase Kinase (Mek-Dependent) Active Transport Mechanism
por: Adachi, Makoto, et al.
Publicado: (2000)

Induction of MAP kinase phosphatase 3 through Erk/MAP kinase activation in three oncogenic Ras (H-, K- and N-Ras)-expressing NIH/3T3 mouse embryonic fibroblast cell lines
por: Koo, JaeHyung, et al.
Publicado: (2016)

The regulation of oncogenic Ras/ERK signalling by dual-specificity mitogen activated protein kinase phosphatases (MKPs)
por: Kidger, Andrew M., et al.
Publicado: (2016)

A Quantitative Model of ERK MAP Kinase Phosphorylation in Crowded Media
por: Aoki, Kazuhiro, et al.
Publicado: (2013)

The Non-Classical MAP Kinase ERK3 Controls T Cell Activation
por: Marquis, Miriam, et al.
Publicado: (2014)

The Complexity of the ERK/MAP-Kinase Pathway and the Treatment of Melanoma Skin Cancer
por: Wellbrock, Claudia, et al.
Publicado: (2016)

Differential Modulation of the Phosphoproteome by the MAP Kinases Isoforms p38α and p38β
por: Melamed Kadosh, Dganit, et al.
Publicado: (2023)

Psoriasis and Gut Microbiome—Current State of Art
por: Polak, Karina, et al.
Publicado: (2021)

ERK5 MAP Kinase Regulates Neurogenin1 during Cortical Neurogenesis
por: Cundiff, Paige, et al.
Publicado: (2009)

Correction: The Non-Classical MAP Kinase ERK3 Controls T Cell Activation
Publicado: (2014)

Oncogenic potential of BEX4 is conferred by Polo-like kinase 1-mediated phosphorylation
por: Lee, Jin-Kwan, et al.
Publicado: (2018)

Tumor-intrinsic oncogene pathways mediating immune avoidance
por: Spranger, Stefani, et al.
Publicado: (2015)

Modulation of the immune microenvironment by tumor-intrinsic oncogenic signaling
por: Nguyen, Kim Bich, et al.
Publicado: (2019)

Adiponectin inhibits neutrophil apoptosis via activation of AMP kinase, PKB and ERK 1/2 MAP kinase
por: Rossi, Alessandra, et al.
Publicado: (2013)

Erk1/2 MAP kinases are required for epidermal G2/M progression
por: Dumesic, Phillip A., et al.
Publicado: (2009)

BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival
por: Jacque, Emilie, et al.
Publicado: (2015)

Regulatory roles of conserved phosphorylation sites in the activation T-loop of the MAP kinase ERK1
por: Lai, Shenshen, et al.
Publicado: (2016)

Control of cell death and mitochondrial fission by ERK1/2 MAP kinase signalling
por: Cook, Simon J., et al.
Publicado: (2017)

Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5
por: Gilbert, Andrew S., et al.
Publicado: (2017)

ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1
por: Bardwell, A Jane, et al.
Publicado: (2022)

CRF(1) Receptor Signaling via the ERK1/2-MAP and Akt Kinase Cascades: Roles of Src, EGF Receptor, and PI3-Kinase Mechanisms
por: Parra-Mercado, G. Karina, et al.
Publicado: (2019)

Systematic identification and correction of annotation errors in the genetic interaction map of Saccharomyces cerevisiae
por: Atias, Nir, et al.
Publicado: (2016)

ERK and JNK Activation is Essential for Oncogenic Transformation by v-Rel
por: Kralova, Jarmila, et al.
Publicado: (2010)

ERK5 is activated by oncogenic BRAF and promotes melanoma growth
por: Tusa, Ignazia, et al.
Publicado: (2018)

Conference on the State of the Art in Numerical Analysis
por: Jacobs, David
Publicado: (1977)

Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors
por: Iyer, Sudarshan R, et al.
Publicado: (2023)

Mesenchymal Transition and PDGFRA Amplification/Mutation Are Key Distinct Oncogenic Events in Pediatric Diffuse Intrinsic Pontine Gliomas
por: Puget, Stephanie, et al.
Publicado: (2012)

Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist
por: Pellegrini, Erika, et al.
Publicado: (2017)

A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing
por: Sinha, Sanju, et al.
Publicado: (2021)

The Oncogenic Functions of MASTL Kinase
por: Marzec, Kamila, et al.
Publicado: (2018)

Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors
por: Lochhead, Pamela A., et al.
Publicado: (2020)

Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers
por: He, Shanshan, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_5taqel1bndp3jh2730h8hrd0qu