NSCLC Mutated Isoforms of CCDC6 Affect the Intracellular Distribution of the Wild Type Protein Promoting Cisplatinum Resistance and PARP Inhibitors Sensitivity in Lung Cancer Cells

CCDC6 is implicated in cell cycle checkpoints and DNA damage repair by homologous recombination (HR). In NSCLC, CCDC6 is barely expressed in about 30% of patients and CCDC6 gene rearrangements with RET and ROS kinases are detected in about 1% of patients. Recently, CCDC6 point-mutations naming E227K...

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Detalles Bibliográficos
Autores principales: Cerrato, Aniello, Morra, Francesco, Di Domenico, Imma, Celetti, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016757/
https://www.ncbi.nlm.nih.gov/pubmed/31877762
http://dx.doi.org/10.3390/cancers12010044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016757/
https://www.ncbi.nlm.nih.gov/pubmed/31877762
http://dx.doi.org/10.3390/cancers12010044

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