Cargando…

Candidate Causal Variants at the 8p12 Breast Cancer Risk Locus Regulate DUSP4

Genome-wide association studies have revealed a locus at 8p12 that is associated with breast cancer risk. Fine-mapping of this locus identified 16 candidate causal variants (CCVs). However, as these variants are intergenic, their function is unclear. To map chromatin looping from this risk locus to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Glubb, Dylan M., Shi, Wei, Beesley, Jonathan, Fachal, Laura, Pritchard, Jayne-Louise, McCue, Karen, Barnes, Daniel R., Antoniou, Antonis C., Dunning, Alison M., Easton, Douglas F., Chenevix-Trench, Georgia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016765/ https://www.ncbi.nlm.nih.gov/pubmed/31936698 http://dx.doi.org/10.3390/cancers12010170

Ejemplares similares

An international initiative to identify genetic modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers: the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA)
por: Chenevix-Trench, Georgia, et al.
Publicado: (2007)

Chromatin interactome mapping at 139 independent breast cancer risk signals
por: Beesley, Jonathan, et al.
Publicado: (2020)

The importance of using public data to validate reported associations
por: Chenevix-Trench, Georgia, et al.
Publicado: (2018)

Functional dissection of breast cancer risk-associated TERT promoter variants
por: Helbig, Sonja, et al.
Publicado: (2017)

A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase
por: Killedar, Anagha, et al.
Publicado: (2015)

Non-coding RNAs underlie genetic predisposition to breast cancer
por: Moradi Marjaneh, Mahdi, et al.
Publicado: (2020)

SNPs in lncRNA Regions and Breast Cancer Risk
por: Suvanto, Maija, et al.
Publicado: (2020)

Enhancing the Promise of Drug Repositioning through Genetics
por: Pritchard, Jayne-Louise E., et al.
Publicado: (2017)

Estimating single nucleotide polymorphism associations using pedigree data: applications to breast cancer
por: Barnes, D R, et al.
Publicado: (2013)

DUSP5 and DUSP6 modulate corneal epithelial cell proliferation
por: Wang, Zheng, et al.
Publicado: (2010)

Analysis of Promoter-Associated Chromatin Interactions Reveals Biologically Relevant Candidate Target Genes at Endometrial Cancer Risk Loci
por: O’Mara, Tracy A., et al.
Publicado: (2019)

No germline mutations in the histone acetyltransferase gene EP300 in BRCA1 and BRCA2 negative families with breast cancer and gastric, pancreatic, or colorectal cancer
por: Campbell, Ian G, et al.
Publicado: (2004)

The application of nonsense-mediated mRNA decay inhibition to the identification of breast cancer susceptibility genes
por: Johnson, Julie K, et al.
Publicado: (2012)

Analysis of the candidate 8p21 tumour suppressor, BNIP3L, in breast and ovarian cancer
por: Lai, J, et al.
Publicado: (2003)

Are estrogen receptor-positive breast cancers in BRCA1 mutation carriers sporadic?
por: Lakhani, Sunil R, et al.
Publicado: (2010)

Splicing annotation of endometrial cancer GWAS risk loci reveals potentially causal variants and supports a role for NF1 and SKAP1 as susceptibility genes
por: Canson, Daffodil M., et al.
Publicado: (2023)

DUSPs, to MAP kinases and beyond
por: Huang, Ching-Yu, et al.
Publicado: (2012)

Improving mid stream urine sampling: reducing labelling error and laboratory rejection
por: Jakes, Adam, et al.
Publicado: (2014)

Association between Common Variation in 120 Candidate Genes and Breast Cancer Risk
por: Pharoah, Paul D. P, et al.
Publicado: (2007)

The cytotoxic action of BCI is not dependent on its stated DUSP1 or DUSP6 targets in neuroblastoma cells
por: Thompson, Elliott M., et al.
Publicado: (2022)

Genome-wide association study and functional follow-up identify 14q12 as a candidate risk locus for cervical cancer
por: Ramachandran, Dhanya, et al.
Publicado: (2022)

Coding for kids for dummies
por: McCue, Camille
Publicado: (2019)

Getting started with coding: get creative with code!
por: McCue, Camille
Publicado: (2019)

Coding for kids for dummies
por: McCue, Camille
Publicado: (2015)

Data mining and predictive analysis: intelligence gathering and crime analysis
por: McCue, Colleen
Publicado: (2007)

Real world print production
por: McCue, Claudia
Publicado: (2007)

Fearless Flash: how to use Adobe InDesign CS5 and the tools you already know to create engaging Web experiences
por: McCue, Claudia
Publicado: (2011)

Real world print production with Adobe Creative Suite applications
por: McCue, Claudia
Publicado: (2009)

Real world print production with Adobe Creative Cloud: industrial-strength production techniques
por: McCue, Claudia
Publicado: (2014)

Helping Kids with Coding For Dummies
por: McCue, Camille
Publicado: (2018)

CRISPR screens identify gene targets at breast cancer risk loci
por: Tuano, Natasha K., et al.
Publicado: (2023)

What is the most dangerous snake?
por: McCue, Marshall D
Publicado: (2013)

The Impact of Medicaid Expansion on Medicaid Focused Insurers in California
por: McCue, Michael J.
Publicado: (2015)

Candidate gene and locus analysis of myopia
por: Mutti, Donald O., et al.
Publicado: (2007)

The androgen receptor CAG repeat polymorphism and modification of breast cancer risk in BRCA1 and BRCA2 mutation carriers
por: Spurdle, Amanda B, et al.
Publicado: (2005)

DUSP4 phosphatase puts the brakes on DLBCL
por: Rickert, Robert
Publicado: (2015)

Proapoptotic function of deubiquitinase DUSP31 in Drosophila
por: Sinenko, Sergey A.
Publicado: (2017)

Investigating the Role of DUSP4 in Uveal Melanoma
por: Aughton, Karen, et al.
Publicado: (2022)

Lack of association between genetic polymorphisms within DUSP12 - ATF6 locus and glucose metabolism related traits in a Chinese population
por: Hu, Cheng, et al.
Publicado: (2011)

A 3’UTR Insertion Is a Candidate Causal Variant at the TMEM106B Locus Associated with Increased Risk for FTLD-TDP
por: Chemparathy, Augustine, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_e2p38tu6h69i02o952vhn5cora