GC bias affects genomic and metagenomic reconstructions, underrepresenting GC-poor organisms

BACKGROUND: Metagenomic sequencing is a well-established tool in the modern biosciences. While it promises unparalleled insights into the genetic content of the biological samples studied, conclusions drawn are at risk from biases inherent to the DNA sequencing methods, including inaccurate abundanc...

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Detalles Bibliográficos
Autores principales: Browne, Patrick Denis, Nielsen, Tue Kjærgaard, Kot, Witold, Aggerholm, Anni, Gilbert, M Thomas P, Puetz, Lara, Rasmussen, Morten, Zervas, Athanasios, Hansen, Lars Hestbjerg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016772/
https://www.ncbi.nlm.nih.gov/pubmed/32052832
http://dx.doi.org/10.1093/gigascience/giaa008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016772/
https://www.ncbi.nlm.nih.gov/pubmed/32052832
http://dx.doi.org/10.1093/gigascience/giaa008

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