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GC bias affects genomic and metagenomic reconstructions, underrepresenting GC-poor organisms
BACKGROUND: Metagenomic sequencing is a well-established tool in the modern biosciences. While it promises unparalleled insights into the genetic content of the biological samples studied, conclusions drawn are at risk from biases inherent to the DNA sequencing methods, including inaccurate abundanc...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016772/ https://www.ncbi.nlm.nih.gov/pubmed/32052832 http://dx.doi.org/10.1093/gigascience/giaa008 |