DCLK1 Monoclonal Antibody-Based CAR-T Cells as a Novel Treatment Strategy against Human Colorectal Cancers

CAR-T (chimeric antigen receptor T cells) immunotherapy is effective in many hematological cancers; however, efficacy in solid tumors is disappointing. Doublecortin-like kinase 1 (DCLK1) labels tumor stem cells (TSCs) in genetic mouse models of colorectal cancer (CRC). Here, we describe a novel CAR-...

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Detalles Bibliográficos
Autores principales: Sureban, Sripathi M., Berahovich, Robert, Zhou, Hua, Xu, Shirley, Wu, Lijun, Ding, Kai, May, Randal, Qu, Dongfeng, Bannerman-Menson, Edwin, Golubovskaya, Vita, Houchen, Courtney W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016951/
https://www.ncbi.nlm.nih.gov/pubmed/31878090
http://dx.doi.org/10.3390/cancers12010054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016951/
https://www.ncbi.nlm.nih.gov/pubmed/31878090
http://dx.doi.org/10.3390/cancers12010054

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