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Binding and Regulation of Transcription by Yeast Ste12 Variants To Drive Mating and Invasion Phenotypes

Amino acid substitutions are commonly found in human transcription factors, yet the functional consequences of much of this variation remain unknown, even in well-characterized DNA-binding domains. Here, we examine how six single-amino acid variants in the DNA-binding domain of Ste12—a yeast transcr...

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Detalles Bibliográficos
Autores principales: Zhou, Wei, Dorrity, Michael W., Bubb, Kerry L., Queitsch, Christine, Fields, Stanley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017024/
https://www.ncbi.nlm.nih.gov/pubmed/31810988
http://dx.doi.org/10.1534/genetics.119.302929