Assembly of a G-Quadruplex Repair Complex by the FANCJ DNA Helicase and the REV1 Polymerase

The FANCJ helicase unfolds G-quadruplexes (G4s) in human cells to support DNA replication. This action is coupled to the recruitment of REV1 polymerase to synthesize DNA across from a guanine template. The precise mechanisms of these reactions remain unclear. While FANCJ binds to G4s with an AKKQ mo...

Descripción completa

Detalles Bibliográficos
Autores principales: Lowran, Kaitlin, Campbell, Laura, Popp, Phillip, Wu, Colin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017153/
https://www.ncbi.nlm.nih.gov/pubmed/31861576
http://dx.doi.org/10.3390/genes11010005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017153/
https://www.ncbi.nlm.nih.gov/pubmed/31861576
http://dx.doi.org/10.3390/genes11010005

Ejemplares similares