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Assembly of a G-Quadruplex Repair Complex by the FANCJ DNA Helicase and the REV1 Polymerase

The FANCJ helicase unfolds G-quadruplexes (G4s) in human cells to support DNA replication. This action is coupled to the recruitment of REV1 polymerase to synthesize DNA across from a guanine template. The precise mechanisms of these reactions remain unclear. While FANCJ binds to G4s with an AKKQ mo...

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Detalles Bibliográficos
Autores principales:	Lowran, Kaitlin, Campbell, Laura, Popp, Phillip, Wu, Colin G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017153/ https://www.ncbi.nlm.nih.gov/pubmed/31861576 http://dx.doi.org/10.3390/genes11010005

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