Cargando…

Discovery and Preliminary Characterization of Translational Modulators that Impair the Binding of eIF6 to 60S Ribosomal Subunits

Eukaryotic initiation factor 6 (eIF6) is necessary for the nucleolar biogenesis of 60S ribosomes. However, most of eIF6 resides in the cytoplasm, where it acts as an initiation factor. eIF6 is necessary for maximal protein synthesis downstream of growth factor stimulation. eIF6 is an antiassociation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pesce, Elisa, Miluzio, Annarita, Turcano, Lorenzo, Minici, Claudia, Cirino, Delia, Calamita, Piera, Manfrini, Nicola, Oliveto, Stefania, Ricciardi, Sara, Grifantini, Renata, Degano, Massimo, Bresciani, Alberto, Biffo, Stefano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017188/ https://www.ncbi.nlm.nih.gov/pubmed/31936702 http://dx.doi.org/10.3390/cells9010172

Ejemplares similares

Inhibition of eIF6 Activity Reduces Hepatocellular Carcinoma Growth: An In Vivo and In Vitro Study
por: Scagliola, Alessandra, et al.
Publicado: (2022)

Translating the Game: Ribosomes as Active Players
por: Calamita, Piera, et al.
Publicado: (2018)

Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma
por: Scagliola, Alessandra, et al.
Publicado: (2021)

Author Correction: Direct and high throughput (HT) interactions on the ribosomal surface by iRIA
por: Pesce, Elisa, et al.
Publicado: (2023)

Expression and activity of eIF6 trigger Malignant Pleural Mesothelioma growth in vivo
por: Miluzio, Annarita, et al.
Publicado: (2015)

Direct and high throughput (HT) interactions on the ribosomal surface by iRIA
por: Pesce, Elisa, et al.
Publicado: (2015)

RACK1 Specifically Regulates Translation through Its Binding to Ribosomes
por: Gallo, Simone, et al.
Publicado: (2018)

Mapping of functional SARS-CoV-2 receptors in human lungs establishes differences in variant binding and SLC1A5 as a viral entry modulator of hACE2
por: Miluzio, Annarita, et al.
Publicado: (2022)

Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation
por: Manfrini, Nicola, et al.
Publicado: (2017)

The β4 Integrin Interactor p27(BBP/eIF6) Is an Essential Nuclear Matrix Protein Involved in 60S Ribosomal Subunit Assembly
por: Sanvito, Francesca, et al.
Publicado: (1999)

SBDS-Deficient Cells Have an Altered Homeostatic Equilibrium due to Translational Inefficiency Which Explains their Reduced Fitness and Provides a Logical Framework for Intervention
por: Calamita, Piera, et al.
Publicado: (2017)

Translational Control of Metabolism and Cell Cycle Progression in Hepatocellular Carcinoma
por: Scagliola, Alessandra, et al.
Publicado: (2023)

Role of microRNAs in translation regulation and cancer
por: Oliveto, Stefania, et al.
Publicado: (2017)

The Translational Machinery of Human CD4(+) T Cells Is Poised for Activation and Controls the Switch from Quiescence to Metabolic Remodeling
por: Ricciardi, Sara, et al.
Publicado: (2018)

mTOR-dependent translation drives tumor infiltrating CD8(+) effector and CD4(+) Treg cells expansion
por: De Ponte Conti, Benedetta, et al.
Publicado: (2021)

Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit
por: Elliff, Jonah, et al.
Publicado: (2023)

Eukaryotic Ribosome Biogenesis: The 60S Subunit
por: Moraleva, A. A., et al.
Publicado: (2022)

eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription
por: Brina, Daniela, et al.
Publicado: (2015)

Binding of eIF3 in complex with eIF5 and eIF1 to the 40S ribosomal subunit is accompanied by dramatic structural changes
por: Zeman, Jakub, et al.
Publicado: (2019)

Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition
por: Llácer, Jose Luis, et al.
Publicado: (2018)

Increased levels of eIF2A inhibit translation by sequestering 40S ribosomal subunits
por: Grove, Daisy J, et al.
Publicado: (2023)

Ribosomal protein L14 contributes to the early assembly of 60S ribosomal subunits in Saccharomyces cerevisiae
por: Espinar-Marchena, Francisco, et al.
Publicado: (2018)

Integrity of the P-site is probed during maturation of the 60S ribosomal subunit
por: Bussiere, Cyril, et al.
Publicado: (2012)

A hierarchical model for assembly of eukaryotic 60S ribosomal subunit domains
por: Gamalinda, Michael, et al.
Publicado: (2014)

Sensitivity of Global Translation to mTOR Inhibition in REN Cells Depends on the Equilibrium between eIF4E and 4E-BP1
por: Grosso, Stefano, et al.
Publicado: (2011)

Pol5 is an essential ribosome biogenesis factor required for 60S ribosomal subunit maturation in Saccharomyces cerevisiae
por: Ramos-Sáenz, Ana, et al.
Publicado: (2019)

Joining the interface: a site for Nmd3 association on 60S ribosome subunits
por: Oeffinger, Marlene
Publicado: (2010)

Mechanistic insight into eukaryotic 60S ribosomal subunit biogenesis by cryo-electron microscopy
por: Greber, Basil J.
Publicado: (2016)

FAM46C Is an Interferon-Stimulated Gene That Inhibits Lentiviral Particle Production by Modulating Autophagy
por: Mancino, Marilena, et al.
Publicado: (2023)

Coupling 40S ribosome recruitment to modification of a cap-binding initiation factor by eIF3 subunit e
por: Walsh, Derek, et al.
Publicado: (2014)

Characterization of the nuclear export adaptor protein Nmd3 in association with the 60S ribosomal subunit
por: Sengupta, Jayati, et al.
Publicado: (2010)

Transcriptional Repressor NIR Functions in the Ribosome RNA Processing of Both 40S and 60S Subunits
por: Wu, Jianguo, et al.
Publicado: (2012)

Has1 regulates consecutive maturation and processing steps for assembly of 60S ribosomal subunits
por: Dembowski, Jill A., et al.
Publicado: (2013)

Identification of the binding site of Rlp7 on assembling 60S ribosomal subunits in Saccharomyces cerevisiae
por: Dembowski, Jill A., et al.
Publicado: (2013)

The nascent polypeptide in the 60S subunit determines the Rqc2-dependency of ribosomal quality control
por: Mizuno, Masato, et al.
Publicado: (2021)

The translational factor eIF3f: the ambivalent eIF3 subunit
por: Marchione, Roberta, et al.
Publicado: (2013)

A Retrospective on eIF2A—and Not the Alpha Subunit of eIF2
por: Komar, Anton A., et al.
Publicado: (2020)

BCCIP is required for nucleolar recruitment of eIF6 and 12S pre-rRNA production during 60S ribosome biogenesis
por: Ye, Caiyong, et al.
Publicado: (2020)

Interaction between the assembly of the ribosomal subunits: Disruption of 40S ribosomal assembly causes accumulation of extra-ribosomal 60S ribosomal protein uL18/L5
por: Rahman, Nusrat, et al.
Publicado: (2020)

Assessment of Sacsin Turnover in Patients With ARSACS: Implications for Molecular Diagnosis and Pathogenesis
por: Longo, Fabiana, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_7e9n7rbchb97ru3htp7t5s90o2